Neurologic Complications of Methanol Poisoning: A Clinicoepidemiological Report from Poisoning Treatment Centers in Tehran, Iran

Eghbali, Hakimeh and Mostafazadeh, Babak and Ghorbani, Mazaher and Behnoush, Behnam (2015) Neurologic Complications of Methanol Poisoning: A Clinicoepidemiological Report from Poisoning Treatment Centers in Tehran, Iran. Asia Pacific Journal of Medical Toxicology, 4 (1). pp. 47-50.

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Abstract

Background: In this study we sought to investigate clinical findings (with a focus on neurologic effects) and also to analyze outcomes of a series of patients with methanol poisoning admitted to two poisoning treatment centers in Tehran, Iran. Methods: In this prospective cross-sectional study, methanol-poisoned patients admitted to departments of forensic medicine and toxicology of Loghman Hakim and Baharloo hospitals in Tehran during October 2010 to October 2011 were included; and their data were recorded in predesigned checklists. Results: Twenty-eight methanol poisoned patients (82.1 men) with mean age of 29.3±4.6 years were studied. Most patients (67.9) had metabolic acidosis at presentation. On admission, all patients had different degrees of decrease in consciousness, who the majority of them (57.1) were admitted with mildly reduced consciousness (grade I of Grady coma scale). Headache and vertigo were observed in 7.1 and 17.9 of patients, respectively. Most patients (53.6) had no ocular effects, while 46.6 of patients developed impaired vision. All patients received sodium bicarbonate. Ethanol as antidote and folic acid were given to 18 patients (64.2) and 16 patients (57.1), respectively. Six patients (21.4) underwent hemodialysis. Over half of the patients (53.6) fully recovered and were discharged without complications. Four patients (14.3) developed total blindness. Four patients (14.3) left the hospital against medical advice by self-discharge (they had no significant complication at the time of discharge). Five patients (17.9) died; who compared to survived cases had significantly lower blood pH (P=0.028), higher coma grade (P<0.001) and more delayed presentation to hospital (P=0.004). Age had no significant impact on mortality.   Conclusion: Methanol poisoning causes major neurologic effects such as coma and blindness. It is also responsible for high mortality.

Item Type: Article
Subjects: QV pharmacology
Divisions: Journals > Asia Pacific J Toxicology
Depositing User: apjmt apjmt
Date Deposited: 07 Oct 2017 15:02
Last Modified: 07 Oct 2017 15:02
URI: http://eprints.mums.ac.ir/id/eprint/7878

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