Antioxidant effects of proanthocyanidin from grape seed on hepatic tissue injury in diabetic rats

Mansouri, Esrafil and Khorsandi, Layasadat and Abedi, Hassan Ali (2014) Antioxidant effects of proanthocyanidin from grape seed on hepatic tissue injury in diabetic rats. Iranian Journal of Basic Medical Sciences, 17 (6). pp. 460-464.

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Abstract

Objective(s):Diabetes plays an important role in the induction of the liver injury. Grape seed proanthocyanidin (GSP) have a wide range of medicinal properties against oxidative stress. In this study we evaluated antioxidant effects of GSP on liver in streptozotocin-induced diabetic rats. Materials and Methods: Thirty male Sprague–Dawley rats were divided into three groups: control, untreated diabetic and diabetic rats treated with GSP. Diabetes was induced in rats by intraperitoneal injection of streptozotocin (50 mg/kg). GSP were administered via oral gavage (200 mg/kg) for 4 weeks. Results: GSP produced significant hepatoprotective effects by decreasing activities of serum aminotransferases and alkaline phosphatase, and decreasing liver malondialdehyde and bilirubin (P<0.05) levels. It increased liver superoxide dismutase, catalase and glutathione peroxidase activities and albumin level (P<0.05). Administration of GSP significantly ameliorated structural changes induced in liver of diabetic rats. Conclusion: GSP have protective effects against hepatic tissue injury due to antioxidant properties.

Item Type: Article
Subjects: QV pharmacology
Divisions: Journals > Iranian J Basic Medical Sciences
Depositing User: ijbms ijbms
Date Deposited: 07 Oct 2017 17:58
Last Modified: 07 Oct 2017 17:58
URI: http://eprints.mums.ac.ir/id/eprint/7904

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