Neuromodulatory role of Bacopa monnieri on oxidative stress induced by postnatal exposure to decabromodiphenyl ether (PBDE -209) in neonate and young female mice

Verma, Priya and Singh, Poonam and S. Gandhi, Behrose (2014) Neuromodulatory role of Bacopa monnieri on oxidative stress induced by postnatal exposure to decabromodiphenyl ether (PBDE -209) in neonate and young female mice. Iranian Journal of Basic Medical Sciences, 17 (4). pp. 307-311.

[img]
Preview
Text
IJBMS_Volume 17_Issue 4_Pages 307-311.pdf

Download (709kB) | Preview
Official URL: http://ijbms.mums.ac.ir/article_2590.html

Abstract

Objective(s):Bacopa monnieri (BM),a traditional ayurvedic medicine,is a well-known memory enhancer. We have explored the role of BM against decabrominated diphenyl ether (PBDE-209)-induced alterations in neonate and young female mice. Materials and Methods: Mice were orally administered with B. monnieri at the doses of 40, 80 or 120 mg/kg body weight along with PBDE-209 (20 mg/kg body weight) from postnatal day (PND) 3-10. Levels of malondialdehyde, protein carbonyl and activities of superoxide dismutase and glutathione peroxidase were measured at both ages. The correct choices and reference/working memory errors of young mice were evaluated by Morris water and radial arm maze. Results: The results showed that BM at the dose of 120 mg/kg significantly (P<0.05) restored the levels of oxidants and the activities of antioxidant enzymes in frontal cortex and hippocampus of neonates against PBDE-209-induced toxicity. Conclusion: BM plays a neuroprotective role against PBDE-209-induced alterations in oxidative status.

Item Type: Article
Subjects: QV pharmacology
Divisions: Journals > Iranian J Basic Medical Sciences
Depositing User: ijbms ijbms
Date Deposited: 08 Oct 2017 14:59
Last Modified: 08 Oct 2017 14:59
URI: http://eprints.mums.ac.ir/id/eprint/7929

Actions (login required)

View Item View Item