Plasma levels of interlukin-4 and Interferon- in patients with chronic or healed cutaneous leishmaniasis

Taheri, Ahmad Reza and Mashayekhi Goyonlo, Vahid and Nahidi, Yalda and Moheghi, Nasrin and Tavakkol Afshari, Jalil (2014) Plasma levels of interlukin-4 and Interferon- in patients with chronic or healed cutaneous leishmaniasis. Iranian Journal of Basic Medical Sciences, 17 (3). pp. 216-219.

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Abstract

Objective(s):In this study, the serum level of interferon-γ (IFN- γ) and interlukin-4 (IL-4) was evaluated as a marker of Th1 and Th2 immune response that influence the clinical course of cutaneous leishmaniasisr1 . Materials and Methods: This cross-sectional study was conducted on 44 cases of cutaneous leishmaniasis (21 cases with healed lesions and 23 cases with chronic non-healing lesions. Thirty-two non-infected persons living in the area were considered as controls. Serum levels of IFN- γ and IL-4 were determined using ELISA, and the results along with clinical data were analyzed using SPSS 11.5. Results: Serum IFN-γ level was not significantly different between various patient groups and control (P=0.27), but the serum level of IL-4 in patient groups was higher than in healthy subjects, and it was higher in patients with non-healed chronic cutaneous leishmaniasis than those with healed lesions (P<0.01). Conclusion: Serum IL-4 level is a good marker for evaluation of the clinical course of cutaneous leishmaniasis.

Item Type: Article
Subjects: QW Microbiology and Immunology
Divisions: Journals > Iranian J Basic Medical Sciences
Depositing User: ijbms ijbms
Date Deposited: 08 Oct 2017 15:43
Last Modified: 08 Oct 2017 15:43
URI: http://eprints.mums.ac.ir/id/eprint/7966

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