Therapeutic Effects of High Dose Intravenous Prednisolone on Methanol Induced Toxic Optic Neuropathy

Abrishami, Mojtaba and Abrishami, Mohammad (2014) Therapeutic Effects of High Dose Intravenous Prednisolone on Methanol Induced Toxic Optic Neuropathy. Asia Pacific Journal of Medical Toxicology, 3 (Supple). p. 13.

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Background: The effects of high dose steroids for the treatment of methanol optic neuropathy was evaluated in this study. Methods: In an interventional case series, 9 patients with a history of sudden visual loss after an ingestion of homemade alcoholic beverages were included in the study. The patients received 250 mg intravenous methyl prednisolone every 6 hours for 4 days continued with oral prednisolone at 1 mg/Kg for 10 days. Best corrected visual acuity (BCVA), optical coherent tomography (OCT), fundus photo, and a complete ophthalmologic exam of the patients were taken before the treatment and 3 months after treatment. Six of them referred before 48 hours and 3 after 72 hours. Results: All patients were men. The mean age was 24.68 ± 4.2 years. In those who referred before 48 hours, the mean BCVA before the treatment was 0.86 ± 0.08 in the right eye (RE) and 0.93 ± 0.1 in the left eye (LE) using the logMAR scale. Four patients showed nerve fiber layer edema as a white density in peripapillary area. After treatment, the mean BCVA in the RE was 0.33 ± 0.18 and 0.29 ± 0.2 in the LE using the logMAR scale. The differences between before and after treatment were significant (P = 0.008 and P = 0.003, respectively). The mean macular thickness and CDR were unchanged. In those who referred after 72 hours, BCVA was not changed significantly (0.96 ± 0.3 and 0.94 ± 0.2 vs. 0.97 ± 0.3 and 0.94 ± 0.2 in RE and LE respectively). Conclusion: Intravenous high dose methyl prednisolone may have benefits in the treatment of methanol optic neuropathy, if initiated before 48 hours.

Item Type: Article
Subjects: QV pharmacology
Divisions: Journals > Asia Pacific J Toxicology
Depositing User: apjmt apjmt
Date Deposited: 11 Oct 2017 19:14
Last Modified: 11 Oct 2017 19:14

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