Effect of whole body vibration therapy on circulating serotonin levels in an ovariectomized rat model of osteoporosis

Huang, Li and Hong Chen, Xian and Wang, Hai-Bin and Sun, Wei-Shan and Chuan Huo., Shao and Qi Li, Zi and Deng, Wei-Min (2014) Effect of whole body vibration therapy on circulating serotonin levels in an ovariectomized rat model of osteoporosis. Iranian Journal of Basic Medical Sciences, 17 (1). pp. 62-68.

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Objective(s): Studies have reported that whole body vibration (WBV) played a vital role in bone remodeling. Circulating serotonin is also involved in negative regulating bone mass in rodents and humans. However, both WBV and inhibition of serotonin biosynthesis may suppress receptor activator of nuclear factor-kappaB ligand (RANKL)-induced osteoclastogenesis in vitro . The purpose of the current study was to investigate the effect of WBV therapy on the levels of serum serotonin in ovariectomized rats. Materials and Methods: Thirty-six-month-old female Sprague Dawley rats weighing 276.15±37.75 g were ovariectomized to induce osteoporosis, and another ten rats underwent sham operation to establish sham control (SHAM) group. After 3 months, ovariectomized rats were divided into three subgroups and then separately treated with WBV, Alendronate (ALN) and normal saline (OVX), SHAM group was given normal saline. After 6 weeks of treatment, rats were sacrificed. Serum serotonin, RANKL, bone turnover markers, and bone mineral density (BMD), bone strength were evaluated. Results: The serum serotonin level was significantly lower in WBV group than OVX and ALN groups (PP<0.001). RANKL levels significantly decreased in WBV and ALN groups compared to OVX group (PPP Conclusion: These data indicated that WBV enhanced the bone strength and BMD in ovariectomized rats most likely by reducing the levels of circulating serotonin

Item Type: Article
Subjects: QT physiology
Divisions: Journals > Iranian J Basic Medical Sciences
Depositing User: ijbms ijbms
Date Deposited: 08 Oct 2017 17:51
Last Modified: 08 Oct 2017 17:51
URI: http://eprints.mums.ac.ir/id/eprint/8055

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