Nephroprotective effects of Feijoa Sellowiana leaves extract on renal injury induced by acute dose of ecstasy (MDMA) in mice

Karami, Mohammad and Karimian Nokabadi, Faezeh and Ebrahimzadeh, Mohammad Ali and Naghshvar, Farshad (2014) Nephroprotective effects of Feijoa Sellowiana leaves extract on renal injury induced by acute dose of ecstasy (MDMA) in mice. Iranian Journal of Basic Medical Sciences, 17 (1). pp. 69-72.

[img]
Preview
Text
IJBMS_Volume 17_Issue 1_Pages 69-72.pdf

Download (732kB) | Preview
Official URL: http://ijbms.mums.ac.ir/article_2159.html

Abstract

Objective(s): Because of the high total phenolic contents of Feijoa sellowiana , its nephroprotective effect was determined in 3,4-methylene dioxymethamphetamine (MDMA) treated mice. Materials and Methods: Animals received 10, 20 and 40 mg/kg doses of aqueous or methanol extract of F. sellowiana leaves, intra-peritoneally. After one hour, an acute administration of MDMA (20 mg/kg, IP) was injected. Nephroprotective effect was assayed by determination of serum creatinine, serum urea and kidney glutathione level. Histopathological study was also used. Results : Both extracts at 40 mg/kg resulted in a significant reversal in the raised serum creatinine levels (P <0.05). Not statistically significant was observed in effect of two extracts (P>0.05). A decrease in urea/ creatinine ratio was observed following aqueous extract treatment. Methanolic extract showed higher activity in increasing kidney glutathione (P Conclusion: F. sellowiana extract resulted in a markedly decrease in the nephrotoxicity of MDMA in mice.

Item Type: Article
Subjects: QV pharmacology
Divisions: Journals > Iranian J Basic Medical Sciences
Depositing User: ijbms ijbms
Date Deposited: 08 Oct 2017 17:52
Last Modified: 08 Oct 2017 17:52
URI: http://eprints.mums.ac.ir/id/eprint/8056

Actions (login required)

View Item View Item