Pathogenesis of Epilepsy: Challenges in Animal Models

Yin, Yow Hui and Ahmad, Nurulumi and Makmor-Bakry, Mohd (2013) Pathogenesis of Epilepsy: Challenges in Animal Models. Iranian Journal of Basic Medical Sciences, 16 (11). pp. 1119-1132.

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Abstract

Epilepsy is one of the most common chronic disorders affecting individuals of all ages. A greater understanding of pathogenesis in epilepsy will likely provide the basis fundamental for development of new antiepileptic therapies that aim to prevent the epileptogenesis process or modify the progression of epilepsy in addition to treatment of epilepsy symptomatically. Therefore, several investigations have embarked on advancing knowledge of the mechanism underlying epileptogenesis, understanding in mechanism of pharmacoresistance and discovering antiepileptogenic or disease-modifying therapy. Animal models play a crucial and significant role in providing additional insight into mechanism of epileptogenesis. With the help of these models, epileptogenesis process has been demonstrated to be involved in various molecular and biological pathways or processes. Hence, this article will discuss the known and postulated mechanisms of epileptogenesis and challenges in using the animal models.

Item Type: Article
Subjects: QT physiology
Divisions: Journals > Iranian J Basic Medical Sciences
Depositing User: ijbms ijbms
Date Deposited: 09 Oct 2017 18:20
Last Modified: 09 Oct 2017 18:20
URI: http://eprints.mums.ac.ir/id/eprint/8070

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