Apolipoprotein E Gene Polymorphism in Iranian Coronary Atherosclerosis Patients Candidate for Coronary Artery Bypass Graft

Heidari, Mohammad Mehdi and Foruzannia, Seyed Khalil and Khatami, Mehri and Hadadzadeh, Mehdi and Emami Meybodi, Mahmoud (2013) Apolipoprotein E Gene Polymorphism in Iranian Coronary Atherosclerosis Patients Candidate for Coronary Artery Bypass Graft. Iranian Journal of Basic Medical Sciences, 16 (7). pp. 841-844.

[img]
Preview
Text
IJBMS_Volume 16_Issue 7_Pages 841-844.pdf

Download (599kB) | Preview
Official URL: http://ijbms.mums.ac.ir/article_1119.html

Abstract

Objective(s): Apolipoprotein E genotype (APOE) polymorphism affects lipid levels and coronary artery disease (CAD) risk. The aim of this study was to study the association of the Apolipoprotein E genotypes with coronary artery disease in the Iranian population. Materials and Methods: The Apolipoprotein E genotype in DNA samples extracted from 66 CAD+ patients and 61 control subjects by restricting enzyme digestion of amplified exon 4 APOE gene was determined. Results : The ε3 allele was found at similar frequency in control subjects (88.5) and atherosclerosis patients (83.3) (P=0.314). Our results showed that the frequency of the ɛ3/ɛ3 and ε3/ε4 genotypes increased in three-vessel-disease patients and the frequency of ɛ2/ɛ2 genotype increased in one-vessel-disease patients. Conclusion : ɛ3/ɛ3 and ɛ3/ɛ4 genotypes are suggested to be predisposing factors, which, in combination with environmental factors, may trigger the degree of luminal narrowing. The possible mechanisms remain elusive and require further studies.

Item Type: Article
Subjects: QT physiology
Divisions: Journals > Iranian J Basic Medical Sciences
Depositing User: ijbms ijbms
Date Deposited: 10 Oct 2017 17:05
Last Modified: 10 Oct 2017 17:05
URI: http://eprints.mums.ac.ir/id/eprint/8122

Actions (login required)

View Item View Item