Comparison and Evaluation of Current Animal Models for Perineural Scar Formation in Rat

O Zanjani, Leila and Firouzi, Masoumeh and Nabian, Mohammad-Hossein and Nategh, Mohsen and Rahimi-Movaghar, Vafa and S Kamrani, Reza (2013) Comparison and Evaluation of Current Animal Models for Perineural Scar Formation in Rat. Iranian Journal of Basic Medical Sciences, 16 (7). pp. 886-890.

IJBMS_Volume 16_Issue 7_Pages 886-890.pdf

Download (453kB) | Preview
Official URL:


Objective (s): Scar formation in injured peripheral nerve bed causes several consequences which impede the process of nerve regeneration. Several animal models are used for scar induction in preclinical studies which target prevention and/or suppression of perineural scar. This study evaluates the translational capacity of four of physical injury models to induce scar formation around the sciatic nerve of rat: laceration, crush, mince and burn. Materials and Methods: Functional (Toe out angle), macroscopic, and microscopic evaluations were performed weekly for four weeks and correlation of findings were analyzed. Result: While macroscopic and microscopic findings suggested a well-developed and adhesive fibrosis surrounding the sciatic nerve, functional assessment did not reveal any significant difference between control and experimental groups (P>0.05). Conclusion: Our study suggests that none of the applied animal models reproduce all essential features of clinical perineural scar formation. Therefore, more studies are needed to develop optimal animal models for translating preclinical investigations

Item Type: Article
Subjects: QV pharmacology
Divisions: Journals > Iranian J Basic Medical Sciences
Depositing User: ijbms ijbms
Date Deposited: 10 Oct 2017 17:35
Last Modified: 10 Oct 2017 17:35

Actions (login required)

View Item View Item