Development of 177Lu-phytate Complex for Radiosynovectomy

Yousefnia, Hassan and Jalilian, Amir Reza and Bahrami-Samani, Ali and Mazidi, Mohammad and Ghannadi Maragheh1, Mohammad and Abbasi-Davani, Fereydoun (2013) Development of 177Lu-phytate Complex for Radiosynovectomy. Iranian Journal of Basic Medical Sciences, 16 (5). pp. 705-709.

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Abstract

Objective(s): In this work a new possible agent for radiosynovectomy has been targeted for articular pain palliation. Materials and Methods: Lu-177 of 2.6-3 GBq/mg specific activity was obtained by irradiation of natural Lu2O3 sample with thermal neutron flux of 4 × 1013 n.cm-2.s-1. The product was converted into chloride form which was further used for labeling of 177Lu-phytate complex and checked using ITLC (MeOH: H2O: acetic acid, 4: 4: 2, as mobile phase). The complex stability and viscosity were checked in the final solution up to seven days. The prepared complex solution (100 µCi/100 µl) was injected intra-articularly to male rat knee joint. Leakage of radioactivity from injection site and its distribution in organs were investigated up to seven days. Results: The complex was successfully prepared with high radiochemical purity (>99.9 ). Approximately, the whole injected dose has remained in injection site seven days after injection. Conclusion: The complex was proved to be a feasible agent for cavital radiotherapy in oncology and rheumatology

Item Type: Article
Subjects: QV pharmacology
Divisions: Journals > Iranian J Basic Medical Sciences
Depositing User: ijbms ijbms
Date Deposited: 14 Oct 2017 17:26
Last Modified: 14 Oct 2017 17:26
URI: http://eprints.mums.ac.ir/id/eprint/8148

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