Anti-angiogenic Effects of Metformin, an AMPK Activator, on Human Umbilical Vein Endothelial Cells and on Granulation Tissue in Rat

Soraya, Hamid and Esfahanian, Nilufar and Shakiba, Yadollah and Ghazi-Khansari, Mahmood and Nikbin, Behroz and Hafezzadeh, Hasan and Maleki Dizaji, Nasrin and Garjani, Alireza (2012) Anti-angiogenic Effects of Metformin, an AMPK Activator, on Human Umbilical Vein Endothelial Cells and on Granulation Tissue in Rat. Iranian Journal of Basic Medical Sciences, 15 (6). pp. 1202-1209.

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Abstract

Objective(s)Metformin is well known for activation of AMP-activated protein kinase (AMPK). AMPK activation inhibits mammalian target of rapamycin (mTOR) as a key signaling process in cell proliferation. Recent epidemiological studies demonstrate that metformin lowers the risk for several types of cancer in diabetic patients. Concerning the critical role of angiogenesis in the incidence and progression of tumors, we investigated the effect of metformin on human umbilical vein endothelial cells migration, as well as on vascular endothelial growth factor (VEGF) expressions in the cells and also on angiogenesis in air pouch model in rats.Materials and MethodsA

Item Type: Article
Subjects: QV pharmacology
Divisions: Journals > Iranian J Basic Medical Sciences
Depositing User: ijbms ijbms
Date Deposited: 23 Oct 2017 15:28
Last Modified: 23 Oct 2017 15:28
URI: http://eprints.mums.ac.ir/id/eprint/8343

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