Is sub-chronic exercise in Combination with medicinal nanoparticles a protective strategy against Doxorubicin-induced Hepatic oxidative stress and apoptosis in aging model rats?

Sadat-Hoseini, Saied Kamal and Dabidi Roshan, Valiollah (2017) Is sub-chronic exercise in Combination with medicinal nanoparticles a protective strategy against Doxorubicin-induced Hepatic oxidative stress and apoptosis in aging model rats? Nanomedicine Journal, 4 (4). pp. 224-231.

[img]
Preview
Text
NMJ_Volume 4_Issue 4_Pages 224-231.pdf

Download (571kB) | Preview
Official URL: http://nmj.mums.ac.ir/article_9432.html

Abstract

Objective(s): Oxidative stress and apoptosis are the major side effects of doxorubicin (DOX) and the advantages accruing fromexercise and some medicinal herbs in mitigation of these toxic side effects is well documented. But so far, the effects of exercise in combination with medicinal nanoparticles on oxidative stress and apoptosis signaling simultaneously, in liver tissue are unknown. Hence, we investigated whether Treadmill Runningin combination with Nanocurcumin protects the liver tissue against these toxic side effects (oxidative stress and apoptosis) simultaneously of DOX treatment in aging rats induced by D-galactose. Materials and Methods: Fifty-six Wistar male rats received a daily injection of D-galactose (100 mg/kg/day, i.p.) then randomly assigned to 7 sub-groups. The training protocol included treadmill running progressively between 25 to 54 min/day and 15 to 20m/min, 5 days/week for six weeks. DOX (1 mg⋅mL−1⋅kg−1⋅day−1) was administrated intraperitoneally for 15 days and Nanocurcumin was administrated orally for 2 weeks (100 mg/kg/day). Results: Nanocurcumin Consumptionled to insignificant increase in SOD, MDA and insignificant decrease in AIF levels. Treadmill runningled to insignificant increase in SOD and insignificant decrease in AIF and MDA levels. The combination of Treadmill runningand Nanocurcumin led to significant decrease in MDA and insignificant increase in SOD and insignificant decrease in AIF levels. Conclusion: In conclusion, Treadmill runningexerciseand Nanocurcumin partly mitigates the toxic side effects of DOX treatment. But this amount of treatment does not play a required role against DOX-induced hepatic damage.

Item Type: Article
Subjects: QT physiology
Divisions: Journals > Nanomedicine Journal
Depositing User: nmj nmj
Date Deposited: 23 Oct 2017 17:59
Last Modified: 23 Oct 2017 17:59
URI: http://eprints.mums.ac.ir/id/eprint/8351

Actions (login required)

View Item View Item