Possible Modulation of the Anexiogenic Effects of Vitex Agnus-castus by the Serotonergic System

Yaghmaei, Parichehr and Oryan, Shahrbanoo and Fatehi Gharehlar, Laleh and Salari, Ali-Akbar and Solati, Jalal (2012) Possible Modulation of the Anexiogenic Effects of Vitex Agnus-castus by the Serotonergic System. Iranian Journal of Basic Medical Sciences, 15 (2). pp. 768-776.

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Objective(s) There is well documented evidence for the increase in widespread use of complementary and alternative medicine in the treatment of physical and psychiatric symptoms and disorders within the populations. In the present study, we investigated the influence of Vitex agnus-castus (vitex) on anxiety-like behaviors of rats. Materials and Methods Elevated plus maze which is one of the methods used for testing anxiety is used in our present study. Rats were orally administrated with vitex for two week. The anxiety test was carried out after two weeks of oral administration of vitex. For evaluating interaction of vitex and serotonergic systems, rats were anaesthetized with ketamine and special cannulas were inserted stereotaxically into the third ventricle (TV) of brain. After 1 week recovery, the effects of serotonegic agents on anxiety were studied. Results Oral administration of vitex (100, 200, 300 mg/kg) for two weeks induced an anxiogenic-like effect which was shown through specific decreases in the percentages of open arm time (OAT ) and open arm entries (OAE ). Intra-TV infusion of 5HT1A receptor agonist, 8-OH-DPAT (5, 10 and 25 ng/rat) increased OAT and OAE, indicating anxiolytic–like behavior. However, injection of 5HT1A receptor antagonist NAN190 (0.25, 0.5 and 1 µg/rat) produced anxiogenic-like behavior. The most effective dose of 8-OH-DPAT (10 ng/rat), when co-administered with vitex (100, 200, 300 mg/kg), attenuated the anxiogenic-like effects of vitex significantly. Injection of the less effective dose of NAN190 (0.5 µg/rat), in combination with vitex (100, 200, 300 mg/kg), potentiate anxiogenic effects of vitex. Conclusions These results illustrate that 5HT1A receptor is involved in the anxiogenic effects of vitex.

Item Type: Article
Subjects: QV pharmacology
Divisions: Journals > Iranian J Basic Medical Sciences
Depositing User: ijbms ijbms
Date Deposited: 31 Oct 2017 16:46
Last Modified: 31 Oct 2017 16:46
URI: http://eprints.mums.ac.ir/id/eprint/8453

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