Effects of Musa sapientum stem extract on experimental models of anxiety

Jielella Reddy, Aditya and Kumar Dubey, Ashok and Handu, Shailendra and Manocha, Sachin and Kumari Mediratta, Pramod and Ahmed Mushtaq, Qazi (2017) Effects of Musa sapientum stem extract on experimental models of anxiety. Avicenna Journal of Phytomedicine, 7 (6). pp. 495-501.

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Abstract

Objective: The Musa sapientum (banana) plant extract has shown antioxidant activity in previous studies. Oxidative stress is one of the important factors implicated in the pathogenesis of anxiety disorders. The present study aimed to evaluate the anxiolytic activity of aqueous extract of M. sapientum stem (MSSE) in experimental models in mice. Material and Methods: Elevated Plus Maze method and locomotor monitoring by photoactometer were used. Animals were divided into five different groups (n=6/group). The vehicle, standard and the experimental groups were given distilled water (10 ml/kg), diazepam (1 mg /kg intraperitoneally) and incremental doses of 25, 50 and 100 mg/kg of MSSE, respectively, prior to the experiment. The standard group received diazepam. Results: The number of open arm entries and the duration of time spent in the open arms in the MSSE-treated groups increased significantly in a dose-dependent manner as compared to that of control group. The duration of time spent in closed arms in the MSSE-treated groups decreased significantly in a dose-dependent manner as compared to that of the control group. MSSE also decreased the locomotor activity significantly at all three test doses. Conclusion: The results of this study suggest an anxiolytic activity for MSSE, which make it a potential natural compound for treatment of anxiety disorders.

Item Type: Article
Subjects: QV pharmacology
W General medicine- Health professions
Divisions: Journals > Avicenna J Phytomedicine
Depositing User: ajp ajp
Date Deposited: 02 Nov 2017 14:53
Last Modified: 02 Nov 2017 14:53
URI: http://eprints.mums.ac.ir/id/eprint/8458

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