Effect of Apium graveolens and Trachyspermum copticom on clinical symptoms of patients with functional dyspepsia

Azimi, Maryam and Zahedi, Mohammad Javad and Mehrabani, Mitra and Tajadini, Haleh and Zolala, Farzaneh and Baneshi, Mohammad and Choopani, Rasool and Sharififar, Fariba and Asadipour, Ali and Hayatbakhsh, Mohammad and Ahmadi, Bijan (2017) Effect of Apium graveolens and Trachyspermum copticom on clinical symptoms of patients with functional dyspepsia. Avicenna Journal of Phytomedicine, 7 (6). pp. 554-564.

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Abstract

Objectives:This study aimed at investigating the effect of Iranian traditional remedy prepared from Apium graveolens and Trachyspermum copticom (AT) on the severity and frequency of symptoms in patients with functional dyspepsia (FD). Material and Methods:In total, 150 FD patients were included in this randomized double-blind trial, based on the ROME III diagnostic criteria, and they were divided into three intervention groups namely, AT, Placebo and omeprazole. Then, severity and frequency of symptoms during this eight-week trial were measured. Obtained information was analyzed using Chi-square test and repeated measures test. Result:In general, the severity and frequency of symptoms after the 4th week significantly decreased in the AT group as compared to the omeprazole and placebo groups, and continued to reduce by the end of the eighth week. General reduction of symptom severity and frequency in the omeprazole group was significantly different from the placebo group by the end of the 4th and 8th weeks. With respect to each individual symptom, AT markedly improved symptoms, such as burning, pain, early satiation, fullness, bloating, belching and nausea, as compared to placebo-treated group. Moreover, AT significantly improved symptoms, like vomiting, and nausea, except for pain, as compared to omeprazole-treated subjects. Conclusion:According to the results, AT, as Iranian traditional remedy, was more effective than omeprazole and placebo in reducing the symptoms in FD patients.

Item Type: Article
Subjects: QY Clinical Pathology
Divisions: Journals > Avicenna J Phytomedicine
Depositing User: ajp ajp
Date Deposited: 02 Nov 2017 14:50
Last Modified: 02 Nov 2017 14:50
URI: http://eprints.mums.ac.ir/id/eprint/8464

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