Is precocious puberty linked to hypothalamic expression of arginine-phenylalanine-amide-related peptide?

He, Yuanyuan and Sun, Wen and Yu, Jian (2017) Is precocious puberty linked to hypothalamic expression of arginine-phenylalanine-amide-related peptide? Iranian Journal of Basic Medical Sciences, 20 (10). pp. 1074-1078.

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Abstract

The up-regulator regulation and down-regulator regulation of gonadotropin-releasing hormone (GnRH) in central precocious puberty is not yet known. However, recent advances in neuroendocrinology have shown the controlling role of arginine-phenylalanine (RF)-amide-related peptides (RFRPs) on GnRH secretion in different phenomenon of reproduction such as estrus cycle and pregnancy, but the exact role of RFRPs in puberty and its related pathologic condition, precocious puberty, is not clear yet. This paper hypothesizes that RFRP is a regulatory peptide of puberty and might prevent the precocious puberty. On the basis of previous studies on hormonal fluctuations at the time of puberty, RFRP might have a role on controlling of premature secretion of GnRH and avoiding central precocious puberty.

Item Type: Article
Subjects: QV pharmacology
Divisions: Journals > Iranian J Basic Medical Sciences
Depositing User: ijbms ijbms
Date Deposited: 04 Nov 2017 14:57
Last Modified: 04 Nov 2017 14:57
URI: http://eprints.mums.ac.ir/id/eprint/8489

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