Therapeutic potential of Juglans regia L. leaf extract against diabetic retinopathy in rat

Nasiry, Davood and Khalatbary, Ali Reza and Ahmadvand, Hassan (2017) Therapeutic potential of Juglans regia L. leaf extract against diabetic retinopathy in rat. Iranian Journal of Basic Medical Sciences, 20 (11). pp. 1275-1281.

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Abstract

Objective(s): Oxidative stress has a pivotal role in the pathogenesis of diabetic retinopathy (DR). Juglans regia L. (JRL) leaf extract has hypoglycemic and antioxidative properties. This study aimed to determine the ameliorative effects of JRL against diabetic retinopathy. Materials and Methods: The DR rat model was generated by injection of streptozotocin (STZ). A subset of the diabetic rats received JRL or metformin after the onset of hyperglycemia. Histopathology and immunohistochemistry of apoptotic and inflammatory factors were assessed along with biochemical assessments of lipid peroxidation and antioxidant status. Results: Lipid peroxidation level and catalase activity significantly improved after JRL consumption (PPP Conclusion: JRL leaf extract exert protective effects against diabetic retinopathy.

Item Type: Article
Subjects: QV pharmacology
Divisions: Journals > Iranian J Basic Medical Sciences
Depositing User: ijbms ijbms
Date Deposited: 04 Nov 2017 16:05
Last Modified: 04 Nov 2017 16:05
URI: http://eprints.mums.ac.ir/id/eprint/8517

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