Comparison of Valproic acid Clearance between Epileptic Patients and Patients with Acute Mania

Mohammadpour, Amir Hooshang and Foroughipour, Mohsen and Azarpazhooh, Mahmoud Reza and Hasanzadeh Khayat, Mohammad and Rezaee, Saeed and Aghebati, Tamara and Shamsara, Jamal (2011) Comparison of Valproic acid Clearance between Epileptic Patients and Patients with Acute Mania. Iranian Journal of Basic Medical Sciences, 14 (6). pp. 546-550.

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Objective(s) The purpose of this study was assessment of the influence of acute manic phase on the steady state pharmacokinetics of valproic acid (VPA) in bipolar patients in comparison with those of epileptic patients. Materials and Methods Ninteen acutely manic and 25 epileptic patients who fulfilled inclusion and exclusion criteria were entered in this prospective study. Blood samples were collected at trough time in steady state and plasma concentrations were determined by fluorescence polarization immunoassay (FPIA). VPA apparent oral clearance (CL/F) values were calculated in each patient and were compared between groups. As VPA clearance is affected by different factors such as age, total body weight, VPA dosage and the use of concurrent medications, all of these confounding factors were made similar in both groups. Results Comparison between two groups showed that CL/F values in acutely manic patients were significantly higher than epileptic patients (10.35±5.77 vs. 7.70±2.63 ml/kg/h, P= 0.047). Conclusion Acutely manic patients require more VPA dosage to achieve serum concentrations in comparison with those found in epileptic patients. It may be suggested that this increased VPA clearance in acute manic phase may be related to abnormalities in membrane transport systems that may affect on cellular uptake of the drug and its volume of distribution. Since our study is a preliminary investigation in this field, further detailed pharmacokinetic study in acute manic patients are warranted to confirm results of this study.

Item Type: Article
Subjects: QV pharmacology
Divisions: Journals > Iranian J Basic Medical Sciences
Depositing User: ijbms ijbms
Date Deposited: 07 Nov 2017 15:08
Last Modified: 07 Nov 2017 15:08

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