qnr Prevalence in Extended Spectrum Beta-lactamases (ESBLs) and None- ESBLs Producing Escherichia coli Isolated from Urinary Tract Infections in Central of Iran

Pakzad, Iraj and Ghafourian, Sohbhan and Taherikalani, Morovat and sadeghifard, Norkhoda and Abtahi, Hamid and Rahbar, Mohammad and Mansory Jamshidi, Neda (2011) qnr Prevalence in Extended Spectrum Beta-lactamases (ESBLs) and None- ESBLs Producing Escherichia coli Isolated from Urinary Tract Infections in Central of Iran. Iranian Journal of Basic Medical Sciences, 14 (5). pp. 458-464.

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Abstract

Objective(s) Extensive use of quinolones has been associated with raising level of resistance. In the current, we focused on assessing the prevalence of Escherichia coli resistance to quinolones and frequency of qnrA, qnrB and qnrS in non ESBLs (extended spectrum beta-lactamases) and ESBLs producing E. coli with blaSHV and blaTEM. Materials and Methods One hundred and fifty E. coli isolates were identified during Mar. 2007 to Apr. 2008 in Milad (Tehran) hospital. They were tested for ESBLs production as well as quinolone resistance. PCR was performed for detection of blaSHV and blaTEM as well as qnrA, B and S. Results Of 150 isolates, forty-two (28) ESBLs producing and one hundred and eight (72) non-ESBLs producing E. coli were identified. 64.2 (n= 24) of E. coli producing ESBLs and 4.62 (n= 5) of non-ESBLs E. coli were resistance to ciprofloxacin. 95.2 (n= 40) and 26.1 (n= 11) of the isolates harbored blaTEM and blaSHV, respectively. 23.8 (n= 10) had both genes. 37.5 (n= 9) and 20.8 (n= 4) of ESBLs producing E. coli were positive for qnrA and qnrB respectively. qnrS was not identified in any isolate. Conclusion Our study showed high frequency of ESBLs producing E. coli as well as quinolone resistance genes (qnrA, qnrB) in Milad hospital.

Item Type: Article
Subjects: QW Microbiology and Immunology
Divisions: Journals > Iranian J Basic Medical Sciences
Depositing User: ijbms ijbms
Date Deposited: 08 Nov 2017 15:21
Last Modified: 08 Nov 2017 15:21
URI: http://eprints.mums.ac.ir/id/eprint/8561

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