A Comparative Study upon the Therapeutic Indices of Some Natural and Synthetic Anti-inflammatory Agents

Khodadadi, Ali and Pipelzadeh, Mohammad Hassan and Aghel, Nasrin and Esmaeilian, Majid and Zali, Iman (2011) A Comparative Study upon the Therapeutic Indices of Some Natural and Synthetic Anti-inflammatory Agents. Iranian Journal of Basic Medical Sciences, 14 (4). pp. 340-348.

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Objective(s) The aim of the present study was to compare the therapeutic indices of several agents used in treatment of inflammatory conditions which included: Vitamin E, hydro-alcoholic extracts of Glycyrrhiza glabra, Matricaria aurea, dexamethasone, piroxicam and diclofenac using Wehi-164 fibrosarcoma cells. Materials and Methods Cytotoxicity evaluation was based on vital dye exclusion assay. Matrix-metalloproteinases inhibition (MMPI) was assessed by gelatinase zymography method. The collected data were used to estimate the IC50 (50 MMPI concentration), LC50 (50 cytotoxicity concentration) and the therapeutic index (LC50/IC50). Results Among the natural anti-inflammatory agents used, M. aurea was the least toxic and the most effective inhibitor of MMP. Vitamin E not only increased MMP activity, but also was the most toxic of all the agents tested. Next in terms of toxicity to vitamin E was G. glabra. Diclofenac was more toxic than both piroxicam and dexamethasone. Conclusion Findings from this study suggest that medicinal plants reputed to have anti-inflammatory properties are not equally effective and safe. In order to assess the implications of these findings, further in vitro and in vivo studies are needed.

Item Type: Article
Subjects: QV pharmacology
Divisions: Journals > Iranian J Basic Medical Sciences
Depositing User: ijbms ijbms
Date Deposited: 21 Nov 2017 15:25
Last Modified: 21 Nov 2017 15:25
URI: http://eprints.mums.ac.ir/id/eprint/8570

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