Anxiolytic-like Effect of Testosterone in Male Rats: GABAC Receptors Are Not Involved

Roohbakhsh, Ali and Hajizadeh Moghaddam, Akbar and Mahmoodi Delfan, Karim (2011) Anxiolytic-like Effect of Testosterone in Male Rats: GABAC Receptors Are Not Involved. Iranian Journal of Basic Medical Sciences, 14 (4). pp. 376-382.

[img]
Preview
Text
IJBMS_Volume 14_Issue 4_Pages 376-382.pdf

Download (146kB) | Preview
Official URL: http://ijbms.mums.ac.ir/article_5027.html

Abstract

Objective(s) The effect of testosterone on anxiety-like behaviors has been the subject of some studies. There is evidence that testosterone modulates anxiety via GABA (gama aminobutyric acid) and GABAergic system. The involvement of GABAC receptors in those effects of testosterone on anxiety-like behaviors of the rats was investigated in the present study. Materials and Methods A group of rats received subcutaneous injections of testosterone (5, 10 and 20 mg/kg). Two groups of rats received intracerebroventricular injections of either CACA (GABAC agonist, 0.125 pg/rat) or TPMPA (GABAC antagonist, 3 microg/rat) following administration of testosterone (5, 10 and 20 mg/kg). After the injections, the rats were submitted to the elevated plus-maze test of anxiety. Results The rats received testosterone alone, showed a decreased in anxiety-like behaviors (P< 0.01). Administration of either CACA or TPMPA did not modify animals’ behavior compared to the rats received testosterone alone. Conclusion The results of the present study showed that administration of testosterone induces anxiolytic-like behaviors in the rats and GABAC receptors possibly are not involved in the anxiolytic effect of testosterone.

Item Type: Article
Subjects: QV pharmacology
Divisions: Journals > Iranian J Basic Medical Sciences
Depositing User: ijbms ijbms
Date Deposited: 21 Nov 2017 15:40
Last Modified: 21 Nov 2017 15:40
URI: http://eprints.mums.ac.ir/id/eprint/8575

Actions (login required)

View Item View Item