Polymorphisms within Exon 9, But Not Intron 8, of the Vitamin D Receptor Gene Are Associated with Asthma

Kazemi Arababadi, Mohammad and Abousaidi, Hamid and Hassanshahi, Gholamhossein and Pourfathollah, Ali Akbar and Daneshmandi, Saeed and Akbarpour, Vajihe and Hakimi, Hamid and Kennedy, Derek (2011) Polymorphisms within Exon 9, But Not Intron 8, of the Vitamin D Receptor Gene Are Associated with Asthma. Iranian Journal of Basic Medical Sciences, 14 (3). pp. 225-230.

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Abstract

Objective(s) Deregulation of the immune system through allied factors and cytokine responses are thought to be important contributors to the pathogenesis of asthma. Vitamin D3 and its nuclear receptor appear to be factors that maybe involved in regulating immune responses during the progression of asthma. The aim of this study was to investigate the association between polymorphisms in intron 8 and exon 9 of the vitamin D receptor (VDR) and this disease. Materials and Methods This study was performed on 100 asthmatic patients and 100 healthy controls. PCR-RFLP was performed to examine polymorphisms in intron 8 and exon 9 of VDR gene. Results Our results showed a statistically significant difference in the Taq-1 evaluated genotypes of exon 9 of the VDR gene when comparing healthy patients to asthmatic patients. Conclusion Based on our results, it can be concluded that VDR and its functional polymorphisms may play an important role in the pathogenesis of asthma.

Item Type: Article
Subjects: QT physiology
Divisions: Journals > Iranian J Basic Medical Sciences
Depositing User: ijbms ijbms
Date Deposited: 12 Dec 2017 18:55
Last Modified: 12 Dec 2017 18:55
URI: http://eprints.mums.ac.ir/id/eprint/8607

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