Protective Effect of Diosgenin and Exercise Training on Biochemical and ECG Alteration in Isoproterenol- Induced Myocardial Infarction in Rats

Salimeh, Afshin and Mohammadi, Mustafa and Mohaddes, Gisou and Badalzadeh, Reza (2011) Protective Effect of Diosgenin and Exercise Training on Biochemical and ECG Alteration in Isoproterenol- Induced Myocardial Infarction in Rats. Iranian Journal of Basic Medical Sciences, 14 (3). pp. 264-274.

[img]
Preview
Text
IJBMS_Volume 14_Issue 3_Pages 264-274.pdf

Download (150kB) | Preview
Official URL: http://ijbms.mums.ac.ir/article_5004.html

Abstract

Objective(s) Several studies have reported improved response of exercised hearts to myocardial infarction (MI). This study was aimed to evaluate the preventive role of treadmill exercise and diosgenin on cardiac marker enzymes, thiobarbituric acid reactive substances (TBARS), total antioxidant status (TAS), lipids, and electrocardiographic (ECG) patterns in isoproterenol (ISO)-induced myocardial infarction (MI) in male Wistar rats. Materials and Methods One hundred Wistar rats were divided into ten groups: Control rats (C), saline (S), L-cremephor (LC), exercise (E), diosgenin dissolved in L-cremephor (15 mg/kg/day) (D), exercise+ diosgenin (E+D), ISO injected (150 mg/kg) (ISO), exercise + ISO (E+ISO), diosgenin + ISO (D+ISO) and exercise+ diosgenin+ ISO (E+D+ISO). At the end of the experiment all animals anesthetized and blood samples were collected for biochemical estimation and also the ECG patterns were recorded. Results Exercise and diosgenin pretreatment significantly decreased the lactate dehydrogenase (LDH) and TBARS level in ISO injected animals. Exercise and diosgenin pretreatment significantly decreased serum total cholesterol and increased high density lipoprotein (HDL-C). ISO-treated rats showed pathological Q waves along with elevated ST segments. The altered electrocardiograms (ECG) of ISO-treated rats were also restored to near normal by diosgenin and exercise, but exercise and diosgenin had synergistic effects. Conclusion The present investigation demonstrates that combination of diosgenin and exercise exhibited significant protection against ISO induced electrocardiographical and biochemical changes. The cadioprotective mechanism(s) appear to be through changing lipid metabolism.

Item Type: Article
Subjects: QU Biochemistry
Divisions: Journals > Iranian J Basic Medical Sciences
Depositing User: ijbms ijbms
Date Deposited: 12 Dec 2017 18:24
Last Modified: 12 Dec 2017 18:24
URI: http://eprints.mums.ac.ir/id/eprint/8612

Actions (login required)

View Item View Item