Glucose Oral Solution as A Pain-Relieving Agent In Infantile Colic: A Double Blinded Randomized Clinical Trial

Shahramian, Iraj and Moradi, Mandana and Afshari, Mahdi and Delaramnasab, Mojtaba and Sargazi, Alireza and Ebrahimi, Mahvash and Bazi, Ali (2017) Glucose Oral Solution as A Pain-Relieving Agent In Infantile Colic: A Double Blinded Randomized Clinical Trial. International Journal of Pediatrics, 5 (12). pp. 6529-6537.

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Abstract

Background Infantile colic (IC) is a common painful disorder within early months of life. There is no definitive therapeutics for IC. In present study aimed to assess pain-relieving potential of glucose administration in infantile colic. Materials and Methods This was a double blinded randomized clinical trial performed during May 2015-June 2017 in pediatric ward of Amir-Al-Momenin Hospital, Zabol city, Iran. Overall, 72 infants were randomly assigned to either glucose or simethicone groups (36 infants per group). Treatments were continued for 28 days with either 25 or 30 glucose solution and 2.5 mg/kg simethicone. Outcomes were assessed at the end of the intervention (28 days). Statistical analysis was done in SPSS version 22.0. Results Males and females constituted 20 (55.5), and 16 (45.5) in glucose administrated, and 23 (63.8) and 13 (36.2, P=0.4) in simethicone group respectively. The mean age (days) was 19.1±3.8 and 20.2±4.9 for glucose and simethicone administrated groups, respectively (P=0.2). The crying times per day significantly reduced in both groups (mean reduction in crying times of 3.7±2.1, and 6.3±2.1 hours in glucose and simethicone groups, respectively). Moreover, 25 and 44.4 of infants in glucose and simethicone groups achieved � 50 reduction in crying time, respectively (P=0.06). According to the glucose dose, infants who received 30 glucose solution significantly revealed higher ratio of � 50 reduction in crying time (47.3) than those received 25 glucose solution in which no cases fulfilled this outcome (P<0.0001). Conclusion Glucose may be a useful candidate to be considered as a pain-relieving agent in infantile colic.

Item Type: Article
Subjects: WA Public Health
WS Pediatrics
Divisions: Journals > International J Pediatrics
Depositing User: IJP IJP
Date Deposited: 10 Dec 2017 14:05
Last Modified: 10 Dec 2017 14:05
URI: http://eprints.mums.ac.ir/id/eprint/8694

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