Effect of Dexamethasone on Striatal Neurotransmissions in the Rats Subjected to Parkinson’s Disease Animal Model

Amanlou, Massoud and Siadat, Seyed Davar and Norouzian, Dariush and Aghasadeghi, Mohammad Reza and Fathi- Moghaddam, Hadi and Piryaei, Mohhamad and Shafiee Ardestani, Mehdi (2011) Effect of Dexamethasone on Striatal Neurotransmissions in the Rats Subjected to Parkinson’s Disease Animal Model. Iranian Journal of Basic Medical Sciences, 14 (2). pp. 107-115.

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Abstract

Objective(s) The aim of this study was to evaluate the effects of dexamethasone on striatal dopaminergic, glutamatergic and gamma amino butyric acid (GABA) ergic neurotransmission in normal and parkinsonian rats. Materials and Methods Dexamethasone (0.15, 0.30, 0.60 and 0.8 mg/kg) was administered to normal or parkinsonian rats (i.p.) followed by the analysis of the striatal neurotransmitters concentrations. Additionally, the effect of dexamethasone on the damaged Substantia nigra pars compata (SNc) neurons has been investigated. Results Dexamethasone resulted in decreased level of striatum glutamatergic-GABAergic and enhanced dopaminergic neurotransmission in normal and parkinsonian rats. In addition, acute treatment with dexamethasone did not improve the lesion at all. Conclusion These findings suggest the new therapeutic mechanism of action for dexamethasone in Parkinson’s disease animal model.

Item Type: Article
Subjects: QV pharmacology
Divisions: Journals > Iranian J Basic Medical Sciences
Depositing User: ijbms ijbms
Date Deposited: 13 Dec 2017 16:54
Last Modified: 13 Dec 2017 16:54
URI: http://eprints.mums.ac.ir/id/eprint/8712

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