Antimalarial and cytotoxic activities of roots and fruits fractions of Astrodaucus persicus extract

Goodarzi, Saied and Nateghpour, Mehdi and Asgharian, Parina and Hadjiakhoondi, Abbas and Yassa, Narguess and Tavakoli, Saeed and Mirzaei, Jalal and Farivar, Leila and Motevalli Haghi, Afsaneh and Tofighi, Zahra (2017) Antimalarial and cytotoxic activities of roots and fruits fractions of Astrodaucus persicus extract. Iranian Journal of Basic Medical Sciences, 20 (12). pp. 1318-1323.

[img]
Preview
Text
IJBMS_Volume 20_Issue 12_Pages 1318-1323.pdf

Download (1MB) | Preview
Official URL: http://ijbms.mums.ac.ir/article_9554.html

Abstract

Objective(s):Astrodaucus persicus (Apiaceae) is one of the two species of this genus which grows in different parts of Iran. Roots of this plant were rich in benzodioxoles and used as food additive or salad in Iran and near countries. The aim of present study was evaluation of antimalarial and cytotoxic effects of different fractions of A. persicus fruits and roots extracts. Materials and Methods: Ripe fruits and roots of A. persicuswere extracted and fractionated by hexane, chloroform, ethyl acetate and methanol, separately. Antimalarial activities of fractions were performed based on Plasmodium berghei suppressive test in mice model and percentage of parasitemia and suppression were determined for each sample. Cytotoxicity of fruits and roots fractions were investigated against human breast adenocarcinoma (MCF-7), colorectal carcinoma (SW480) and normal (L929) cell lines by MTT assay and IC50 of them were measured. Results: Hexane fraction of roots extract (RHE) and ethyl acetate fraction of fruits extract (FEA) of A. persicus demonstrated highest parasite inhibition (73.3 and 72.3, respectively at 500 mg/kg/day) which were significantly different from negative control group (P<0.05). In addition, RHE showed potent anticancer activities against MCF-7 (IC50 of 0.01 µg/ml), SW480 (IC50 of 0.36 µg/ml) and L929 (IC50 of 0.70 µg/ml) cell lines. Conclusion: According to the results, RHE and FEA fractions of A. persicus could be introduced as excellent choice for antimalarial drug discovery. In addition, cytotoxic activity of RHE was noticeable.

Item Type: Article
Subjects: QV pharmacology
Divisions: Journals > Iranian J Basic Medical Sciences
Depositing User: ijbms ijbms
Date Deposited: 23 Dec 2017 16:56
Last Modified: 23 Dec 2017 16:56
URI: http://eprints.mums.ac.ir/id/eprint/8804

Actions (login required)

View Item View Item