Neuroprotection of a sesamin derivative, 1, 2-bis (3-methoxy- phenyl) methyl ethane-1, 2-dicaroxylic acid (MMEDA) against ischemic and hypoxic neuronal injury

Hung, Chang-Tsen and Chen, Li-Dian and Hou, Chien-Wei (2017) Neuroprotection of a sesamin derivative, 1, 2-bis (3-methoxy- phenyl) methyl ethane-1, 2-dicaroxylic acid (MMEDA) against ischemic and hypoxic neuronal injury. Iranian Journal of Basic Medical Sciences, 20 (12). pp. 1324-1330.

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Abstract

Objective(s): Stroke may cause severe neuronal damage. The sesamin have been demonstrated to possess neuroprotection by its antioxidant and anti-inflammatory properties. One sesamin derivative was artificially composited, 1, 2-bis (3-methoxyphenyl) methyl ethane-1, 2-dicaroxylic acid (MMEDA) had been developed to study its antioxidative activity and neuroprotection. Materials and Methods: The infaction of Sprague Dawley (SD) rats and hypoxia models of BV-2 microglia or PC12 cells were investigated for in vivo and in vitro test respectively. Lipid peroxidation and reactive oxygen species (ROS), prostaglandin E2 (PGE2) and related signaling pathways from hypoxic cells were analyzed by ELISA or Western blot assay, respectively. Results: MMEDA showed a protective effect when given 90 min after the focal cerebral ischemia. The neuroprotection of MMEDA was further confirmed by attenuating ROS and PGE2 release from hypoxic BV-2 or PC12 cells. MMEDA significantly reduced hypoxia-induced JNK and caspase-3 (survival and apoptotic pathways) in PC12 cells. Conclusion: The neuroprotective effect of MMEDA on ischemia/hypoxia models was involved with its antioxidative activity and anti-inflammatory effects. These results suggest that MMEDA exert effective neuroprotection against ischemia/hypoxia injury.

Item Type: Article
Subjects: QV pharmacology
Divisions: Journals > Iranian J Basic Medical Sciences
Depositing User: ijbms ijbms
Date Deposited: 23 Dec 2017 16:58
Last Modified: 23 Dec 2017 16:58
URI: http://eprints.mums.ac.ir/id/eprint/8805

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