Sodium hydrosulfide upregulates mRNA and protein expression of TGF-α in gastric mucosa in experimental model of stimulated gastric acid secretion in rats

Akbari, Ghaidafeh and Mard, Seyyed Ali and Khoshnam, Seyed Esmaeil and Ahmadi, Iraj (2017) Sodium hydrosulfide upregulates mRNA and protein expression of TGF-α in gastric mucosa in experimental model of stimulated gastric acid secretion in rats. Iranian Journal of Basic Medical Sciences, 20 (12). pp. 1385-1389.

[img]
Preview
Text
IJBMS_Volume 20_Issue 12_Pages 1385-1389.pdf

Download (1MB) | Preview
Official URL: http://ijbms.mums.ac.ir/article_9597.html

Abstract

Objective(s): Transforming growth factor alpha (TGF-α) has been shown to modulate the gastric acid secretion. Therefore, the aim of the present study was to investigate the effect of sodium hydrosulfide (NaHS) on TGF-α expression in gastric mucosa in rats. Materials and Methods: Eighteen rats were randomly divided into 3 groups (6 per group). To determine the effect of NaHS on gene and protein expression of TGF-α in gastric mucosa in response to gastric acid, the acid output induced by gastric distension. At the end of experiment, rats were euthanized by anesthetics, and gastric effluents, in addition to mucosa were collected to measure the pH of gastric effluents and to quantify protein and gene expression of TGF-α. Results: The stimulated gastric acid upregulated expression levels of TGF-α in gastric mucosa. These levels were higher in animals pretreated with NaHS. Conclusion: TGF-α upregulatory effect of sodium hydrosulfate implied that TGF-α is involved in the acid inhibitory effect of NaHS.

Item Type: Article
Subjects: QV pharmacology
Divisions: Journals > Iranian J Basic Medical Sciences
Depositing User: ijbms ijbms
Date Deposited: 24 Dec 2017 16:09
Last Modified: 24 Dec 2017 16:09
URI: http://eprints.mums.ac.ir/id/eprint/8813

Actions (login required)

View Item View Item