Association between Thrombophilic Gene Polymor-phisms and Recurrent Pregnancy Loss in Iranian Women

Maziri, Parisa and Asaadi Tehrani, Golnaz and Bahrami Hidagi, Fereshteh and Nejatollahi, Masoumeh and Asadi, Sedigheh (2017) Association between Thrombophilic Gene Polymor-phisms and Recurrent Pregnancy Loss in Iranian Women. Iranian Journal of Neonatology IJN, 8 (4). pp. 13-19.

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Abstract

Background: Recurrent pregnancy loss (RPL) is a common problem among couples, and acquired thrombophilia is the well-known etiology of RPL. The aim of this study was to establish the association between inherited thrombophilic gene polymorphisms and RPL. Methods: This case-control study was conducted on 50 women with unexplained RPL and 50 parous women with no history of miscarriage (age range: 17ג��48 years). The data were collected during 2013ג��2015 in Sarem Hospital, Tehran, Iran. Genotyping was performed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) for glycoprotein IIIa (PLA1/PLA2), KDR (Q472H), and \xCE²-fibrinogen (-455G/A); tetra-primer amplification refractory mutation system (ARMS)-PCR for glycoprotein Ia (807c/t) and vascular endothelial growth factor (VEGF) (2578c/a), and ins/del PCR for angiotensin I-converting enzyme (ACE) (intron 16 I/D). The association between the frequency of the genotypes and RPL was determined by Chi-square and Fisherג��s exact tests. Results: The results of the present study revealed a significant relationship between glycoprotein Ia (807C/T), VEGF (2578C/A), and ACE (intron 16 I/D) polymorphisms and RPL (P=0.00, 0.02, and 0.00, respectively). In contrast, no relationship was observed between \xCE²-fibrinogen (-455G/A), KDR (Q472H), and glycoprotein IIIa (PLA1/PLA2) polymorphisms and increased risk of RPL (P>0.05). Conclusion: This study demonstrated that glycoprotein Ia (807C/T), VEGF (2578C/A), and ACE (intron 16 I/D) polymorphisms may be a risk factor for the women with a history of RPL. \xC2

Item Type: Article
Subjects: WS Pediatrics
Divisions: Journals > Iranian J Neonatology
Depositing User: ijn ijn
Date Deposited: 30 Dec 2017 14:58
Last Modified: 30 Dec 2017 14:58
URI: http://eprints.mums.ac.ir/id/eprint/8890

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