Effect of autologous Bone marrow stem cell on panel reactive Antibodies in patients with chronic and progressive renal failure, a pilot clinical trial

Sadeghnia, Roya and Naghibi, Masih and Sharifipour, Farzaneh and Ravari, Hassan and Hamidi Alamdari, Dariush and Esmaili, Habibolah and Mamduhi, Fereshte and Rahimi, Hamidreza (2017) Effect of autologous Bone marrow stem cell on panel reactive Antibodies in patients with chronic and progressive renal failure, a pilot clinical trial. medical journal of mashhad university of medical sciences, 60 (2). pp. 450-460.

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Abstract

Background: In vitro and in vivo immunosuppressive properties have been described for Mesenchymal stem cells (MSCs), as they are able to modulate the function of all major immune cell populations. They represent important candidates for tissue regeneration and manipulation of the immune response in graft rejection, graft versus host disease, and autoimmune disorders. The aim of this study was to evaluate effect of autologous bone marrow stem cell on panel reactive Antibodies in patients with chronic and progressive renal failure. Subjects&Method: This is a pilot study on 17 patients with CFR (9 in intervention group and 8 in control group). Panel reactive Anti bodies before and after injections of stem cells from bone marrow that containing acceptable percentage of Mesenchymal stem cell in the intervention group compared with the control group. The 200 cc to 400 cc bone marrow aspirated then nucleated cells separated from red blood cells , then these cells injected to peripheral vein. Results: Mean age was 41.8±12.37 and 40.37±12.65 in intervention and control group respectively, with no significant differences were found between them (P=0.807). Mean panel antibody reaction was 69.86±6.24 and 70.25±13.46 in the intervention and control group respectively, no significant difference between them (P=0.956). After intervention, according to the pair T test there was a significant difference between before and after (51.55±26.44) panel antibody reaction (P=0.043). Conclusion: Infusion of allograft mesenchymal stem cells, might be an effective therapy for patients with high panel reactive Antibodies.

Item Type: Article
Subjects: WA Public Health
Divisions: Journals > Medical J Mashhad University of Medical Sciences
Depositing User: mjmums mjmums
Date Deposited: 25 Jan 2018 14:20
Last Modified: 25 Jan 2018 14:20
URI: http://eprints.mums.ac.ir/id/eprint/9035

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