Evaluation of the association between Morphea and Cytomegalovirus in a cross sectional study

Nahidi, Yalda and Tayyebi Meibodi, Naser and Meshkat, Zahra and Salehi, Maryam and Farhangdoost, Fatemeh (2017) Evaluation of the association between Morphea and Cytomegalovirus in a cross sectional study. medical journal of mashhad university of medical sciences, 60 (3). pp. 494-502.

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Abstract

Introduction: Morphea is the most common variety of localized scleroderma, which forms a spectrum of sclerotic diseases that primarily affect the skin. The etiology and pathogenesis of morphea is not yet known; however, a multifactorial process is assumed to trigger an inflammatory and fibrotic cascade. The potential environmental factors involved include Lyme disease, trauma, radiation, drugs, and viral infections such as Cytomegalovirus (CMV). In this study, we sought to assess the relationship between morphea and CMV. Materials and Methods: Amplification of CMV DNA was detected by PCR on 41 paraffin-embedded tissue sections of morphea patients and 40 healthy skin samples. Data were analyzed by SPSS ver.16 and P ≤ 0.05 was considered statistically significant. Results: Among 41 patients, there were 17 males (17) and 34 females(83). Minimum and maximum age of patients was 12 and 72 years, respectively with mean age of 43.5 years. Among 81 beta globin positive samples, CMV DNA was detected in nearly all samples of morphea patients as well as healthy skin samples. Only one sample from case group (2.4) and two samples from control group (5) were negative for CMV DNA(P=0.61). Conclusion: In this study, no significant correlation was found between the amplification of CMV DNA and morphea disease.

Item Type: Article
Subjects: WA Public Health
Divisions: Journals > Medical J Mashhad University of Medical Sciences
Depositing User: mjmums mjmums
Date Deposited: 25 Jan 2018 14:31
Last Modified: 25 Jan 2018 14:31
URI: http://eprints.mums.ac.ir/id/eprint/9042

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