Effect of Treatment with Vitamin D on Maternal and Neonatal Indices in Pregnant Women with Hypocalcemia: A Randomized Controlled Trial

Abotorabi, Shokohossadat and Hashemi Poor, Sima and Esmailzadehha, Neda and Ziaee, Amir and Khoeiniha, Mohammad Hossein (2017) Effect of Treatment with Vitamin D on Maternal and Neonatal Indices in Pregnant Women with Hypocalcemia: A Randomized Controlled Trial. International Journal of Pediatrics, 5 (9). pp. 5733-5739.

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Abstract

Background The impact of concomitant vitamin D deficiency and maternal hypocalcemia on fetal growth has is not clear. The aim of this study was to determine the effect of treatment with vitamin D on maternal and neonatal indices in pregnant women with hypocalcemia. Materials and Methods This clinical trial was conducted on 110 pregnant women (22-26 weeks of gestational age) with simultaneous mild hypocalcemia (8 < serum calcium< 8.5 mg/dL) and vitamin D deficiency (25 (OH) D< 75 nmol/L). The study subjects were randomly allocated to intervention (n=55) and control (n=55) groups. In the control group, the subjects were given daily prenatal capsule until delivery. In the intervention group, the subjects were given 50,000 Units vitamin D weekly for eight weeks in addition to prenatal capsules until delivery similar to the control group. At delivery, maternal calcium and 25 (OH) D level and neonatal indices (weight, height, and head circumference) were measured and compared between the groups. Results At delivery, mean maternal vitamin D level was 97.5±23.4 nmol/L in the intervention group and 48.9±17.2 nmol/L in the control group, respectively (P<0.001). Mean maternal calcium level in the intervention group was higher than the control group (9.0±0.6 mg/dl vs. 8.8±0.5 mg/dl) but the difference was not statistically significant (P>0.05). Mean neonatal weight, height, and head circumference were not significantly different between the two groups (P>0.05). Conclusion In pregnant women with mild hypocalcemia, treatment with vitamin D would not have effect on mean serum calcium and neonatal indices.

Item Type: Article
Subjects: WA Public Health
WP Gynecology
WS Pediatrics
QV pharmacology
Divisions: Journals > International J Pediatrics
Depositing User: IJP IJP
Date Deposited: 20 Sep 2017 23:31
Last Modified: 20 Sep 2017 23:31
URI: http://eprints.mums.ac.ir/id/eprint/952

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