Evaluation of Serum Vitamin D Level in Oral Lichen Planus Patients

Seif, Sepideh and Jafari- ashkavandi, Zohreh and Mardani, Maryam and Hamidizadeh, Nasrin (2018) Evaluation of Serum Vitamin D Level in Oral Lichen Planus Patients. Journal of Mashhad Dental School, 42 (1). pp. 58-49.

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Introduction: Vitamin D is a secosteroid (pro)-hormone with multiple systematic effects, including the regulation of the immune system. Serum vitamin D level affects the progression of some diseases, such as psoriasis and oral cancer. The study aimed to measure the serum vitamin D level in patients with oral lichen planus (OLP), which is an autoimmune and precancerous disease. Materials and Methods: This cross-sectional study was conducted on 66 patients with OLP and 30 healthy individuals. In addition, serum vitamin D level was measured by ELISA method, and data analysis was performed using Mann–Whitney U and t-test. Results: In this research, 26 (39.4) patients with OLP had vitamin D deficiency and 31 (47.0) subjects had an insufficient vitamin D level. On the other hand, 9 (30.0) and 15 (50) of the participants in the control group had vitamin D deficiency and insufficient vitamin D level, respectively. According to the results, no significant relationship was observed in the study groups regarding serum vitamin D levels. However, a reverse and significant correlation was found between age and vitamin D deficiency in the subjects (P=0.015). Conclusion: According to the results of the study, low serum vitamin D levels were observed in a high percentage of patients with OLP. Given the prevalence of vitamin D deficiency in the society, extended research is required to evaluate the impact of this deficiency on pathogenesis of the disease. Keywords: Vitamin D, Oral Lichen Planus, Etiology.

Item Type: Article
Subjects: WU Dentistry. Oral surgery
Divisions: Journals > Journal of Mashhad Dental School
Depositing User: jmds jmds
Date Deposited: 17 Mar 2018 08:20
Last Modified: 17 Mar 2018 08:20
URI: http://eprints.mums.ac.ir/id/eprint/9659

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