Comparison of of Interleukin 23 Level in Gingival Crevicular Fluid between Peri-implantitis and Healthy Patients

Esfahanian, Vahid and Farhad, Shirin Zahra and Bakhtiari, Mohammad and Feyzollahi Almaloo, Mona (2018) Comparison of of Interleukin 23 Level in Gingival Crevicular Fluid between Peri-implantitis and Healthy Patients. Journal of Mashhad Dental School, 42 (2). pp. 115-120.

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Introduction: Peri-implantitis is characterized by irreversible lesions that are caused by microbial plaque, involving not only the soft tissue around the implant, but also the implant-supporting bone. In the peri-implant diseases, some cytokines are increased, and inflammatory mediators, which are observed in peri-implantitis, induce the activation of osteoclasts and bone resorption. The aim of this study was to compare the level of interleukin 23 (IL-23) in patients with peri-implantitis and those with healthy peri-implant tissue. Materials &amp; methods: This clinical trial was conducted on 19 patients with peri-implantitis and 19 patients with healthy peri-implant tissue. The samples were collected from sulcular fluid/gingival pocket fluid by paper cone and placed in vials. The level of IL-23 was determined using ELISA reader. Furthermore, the relationship of IL-23 levels with bleeding, probing depth, and pus formation was analyzed. Data analysis was performed using independent t-test, Pearson correlation coefficient, and Spearman test. Results: According to the results, the level of IL-23 in the patients with peri-implantitis was significantly higher than that in the group with healthy peri-implant tissue (P<0.001). Furthermore, the level of IL-23 showed a direct relationship with probing depth (P=0.008), bleeding on probing (P=0.01), and pus formation (P<0.001) in the patient group. Conclusion: As the findings indicated, the amount of IL-23 in the gingival fluid of the patients with peri-impinitis was higher than that of the healthy subjects. Probing depth, bleeding, and pus formation are directly associated with IL-23. Therefore, the evaluation of IL-23 level can be used in the diagnosis of peri-implantitis.

Item Type: Article
Subjects: WU Dentistry. Oral surgery
Divisions: Journals > Journal of Mashhad Dental School
Depositing User: jmds jmds
Date Deposited: 14 Jun 2018 06:41
Last Modified: 14 Jun 2018 06:41

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