Trans-chalcone enhances insulin sensitivity through the miR-34a/SIRT1 pathway

Karimi Sales, Elham and Jeddi, Sajad and Ebrahimi-Kalan, Abbas and Alipour, Mohammad Reza (2018) Trans-chalcone enhances insulin sensitivity through the miR-34a/SIRT1 pathway. Iranian Journal of Basic Medical Sciences, 21 (4). pp. 359-363.

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Abstract

Objective(s): Trans-chalcone as the parent member of the chalcone series reduces circulating levels of insulin and glucose. However, the cellular mechanism of these effects is poorly understood. Sirtuin 1 (SIRT1) as a direct target of miR-34a controls homeostasis of glucose, and also improves insulin sensitivity. Therefore, the present study for the first time investigated the influence of trans-chalcone on the miR-34a/SIRT1 pathway as a possible mechanism for its hypoglycemic and hypoinsulinemic effects. Materials and Methods: In this study, thirty male rats were randomly divided into three groups (n=10): solvent control (NS), oral administration of trans-chalcone for 2 (N2T) and 6 weeks (N6T) groups. Then, hepatic levels of miR-34a and SIRT1 were measured through the qRT-PCR method.Results: Trans-chalcone reduced food intake, body weight gain, and serum glucose as well as insulin levels. Also, this chalcone inhibited hepatic miR-34a expression and significantly elevated SIRT1 mRNA level. Conclusion: Trans-chalcone as an insulin-sensitizing chalcone partly acts through the miR-34a/SIRT1 pathway.

Item Type: Article
Subjects: QV pharmacology
Divisions: Journals > Iranian J Basic Medical Sciences
Depositing User: ijbms ijbms
Date Deposited: 28 Jul 2018 04:25
Last Modified: 28 Jul 2018 04:25
URI: http://eprints.mums.ac.ir/id/eprint/9932

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