Does inhibition of angiotensin function cause neuroprotection in diffuse traumatic brain injury?

Khaksari, Mohammad and Rajizadeh, Mohammad Amin and Bejeshk, Mohammad Abbas and Soltani, Zahra and Motamedi, Sina and Moramdi, Fatemeh and Islami, Masoud and Shafa, Shahriyar and Khosravi, Sepehr (2018) Does inhibition of angiotensin function cause neuroprotection in diffuse traumatic brain injury? Iranian Journal of Basic Medical Sciences, 21 (6). pp. 615-620.

[img] Text
IJBMS_Volume 21_Issue 6_Pages 615-620.pdf

Download (466kB)
Official URL: http://ijbms.mums.ac.ir/article_10694.html

Abstract

Objective(s): Neuroprotection is created following the inhibition of angiotensin II type 1 receptor (AT1R). Therefore, the purpose of this research was examining AT1R blockage by candesartan in diffuse traumatic brain injury (TBI). Materials and Methods: Male rats were assigned into sham, TBI, vehicle, and candesartan groups. Candesartan (0.3 mg/kg) or vehicle was administered IP, 30 min post-TBI. Brain water and Evans blue contents were determined, 24 and 5 hr after TBI, respectively. Intracranial pressure (ICP) and neurologic outcome were evaluated at -1, 1, 4 and 24 hr after TBI. Oxidant index malondialdehyde (MDA) was determined 24 hr after TBI.Results: Brain water and Evans blue contents, and MDA and ICP levels increased in TBI and vehicle groups in comparison with the sham group. Candesartan attenuated the TBI-induced brain water and Evans blue contents, and ICP and MDA enhancement. The neurologic score enhanced following candesartan administration, 24 hr after TBI.Conclusion: The blockage of AT1R may be neuroprotective by decreasing ICP associated with the reduction of lipid peroxidation, brain edema, and blood-brain barrier (BBB) permeability, which led to the improvement of neurologic outcome.

Item Type: Article
Subjects: QW Microbiology and Immunology
Divisions: Journals > Iranian J Basic Medical Sciences
Depositing User: ijbms ijbms
Date Deposited: 24 Jul 2018 07:54
Last Modified: 24 Jul 2018 07:54
URI: http://eprints.mums.ac.ir/id/eprint/9970

Actions (login required)

View Item View Item